Dexamethasone in bronchopulmonary dysplasia.

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Dexamethasone in bronchopulmonary dysplasia.

Dexamethasone is useful for the treatment of bronchopulmonary dysplasia in premature infants and it is likely that its use will increase. Several side effects have been reported, including an increased incidence of infection. Because glucocorticoids are known to produce neutrophilia in adults (probably through a combination of increased release of neutrophils from the marrow, and prolongation o...

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Dexamethasone increases plasma amino acid concentrations in bronchopulmonary dysplasia.

Nine ventilated low birthweight babies were treated with dexamethasone (0.6 mg/kg/day). Appreciable suppression of weight gain was accompanied by uraemia and significant increases in the concentration of all amino acids except phenylalanine, tyrosine, threonine, and glutamate. Ornithine, citrulline, alanine, glutamine, and cystine concentrations increased threefold or more. The findings could n...

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Dexamethasone treatment in preterm infants at risk for bronchopulmonary dysplasia.

A randomised double blind placebo controlled study was conducted to determine whether a one week course of dexamethasone could reduce the severity of bronchopulmonary dysplasia in preterm infants without compromising their adrenal function. Forty one infants with a mean birth weight of 880 g and a gestational age of 27 weeks who were ventilator dependent at 10 days of age were enrolled. At the ...

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Lipid intolerance in neonates receiving dexamethasone for bronchopulmonary dysplasia.

BACKGROUND We hypothesized that dexamethasone induces hypertriglyceridemia (triglyceride levels >2.82 mmol/L [250 mg/dL]) and increases free fatty acid (FFA) levels and that steroid-induced hypertriglyceridemia is associated with hyperinsulinemia and elevated FFA levels. OBJECTIVE To study the effect of dexamethasone sodium phosphate on lipid metabolism in neonates receiving intravenous lipid...

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Bronchopulmonary Dysplasia

Bronchopulmonary dysplasia (BPD) continues to be the most common and most important complication in preterm infants with RDS. The incidence varies from 20 to 60 % in preterm infants whose weight are < 1500 gram. The presence of BPD is often associated with significant mortality and short term and long term morbidity, including growth failure and neurodevelopment delay. The exact mechanism and p...

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ژورنال

عنوان ژورنال: Archives of Disease in Childhood

سال: 1988

ISSN: 0003-9888,1468-2044

DOI: 10.1136/adc.63.2.221